Overview
Psoriasis is a chronic skin disorder that affects about 2% of the population. It is characterized by red, elevated plaques that are often overlaid with thick, silvery white scales. The most commonly affected areas are the elbows, knees, scalp, lower back, and genitalia. Some people have psoriasis on their hands and feet. A condition called inverse psoriasis manifests plaques in folded areas, such as in the armpits and groin.
While psoriasis can develop at any age, it seems to have two peaks of onset incidence: in the third and sixth decades of life. Psoriasis can be physically and emotionally disabling. This disease is often inherited and carries the potential for causing arthritis (psoriatic arthritis).
Although the likelihood for familial transmission may not seem significant, there is a definite genetic predisposition for psoriasis. When one parent is affected, there is roughly a 10% risk of a child acquiring psoriasis. The risk rises to almost 50% when both parents have psoriasis. One study analyzing psoriasis in twins found 65% of identical twin siblings had psoriasis when the other twin was affected. The exact mode of inheritance is complex and variable. The National Psoriasis Foundation reported that researchers have discovered evidence that psoriasis is an autoimmune disorder.
Most people with psoriasis report that no particular event or illness preceded or brought about their condition, but several well-known triggers include stress, strep infection, and some medications.
Physician-developed and -monitored.
Original Date of Publication: 01 Sep 2000
Reviewed by: Stanley J. Swierzewski, III, M.D.
Last Reviewed: 04 Dec 2007
Psoriasis, Overview, Causes reprinted with permission from dermatologychannel.net
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