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Kidney Stones

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Pain Medications

Over-the-counter pain relievers (e.g., aspirin, Tylenol® , Advil®) usually are not effective by themselves for the more severe pain caused by kidney stones. However, you can try a combination of Aleve® , Advil®, or Motrin® plus Tylenol® for milder pain. Talk to your physician about what dosages of these medications is safe for you to take.

Oral opiod analgesics, such as acetaminophen/codeine (Tylenol with Codeine®), propoxyphene HCL (Darvon®), hydrocodone/acetaminophen (Vicodin®) and oxycodone/acetaminophen (Percocet®) may be prescribed to minimize moderate pain associated with stones.

Injectable medications such as morphine sulfate (Duramorph PF®), hydromorphone (Dilaudid®), and ketorolac HCL (Toradol®) may be administered intravenously (IV) or intramuscularly (by injection) for severe pain. There is a risk for dependency with oral narcotic analgesics used for more than 3–4 weeks at a time and a small risk for accidental overdose if injectable medications are given directly into a vein.

Side effects of these medications include the following:

  • Constipation
  • Drowsiness
  • Nausea
  • Slowed breathing (respiration)
  • Vomiting

Nausea and vomiting can be reduced using medications such as prochlorperazine edisylate (Compazine®), promethazine HCL (Phenergan®), and metoclopramide HCL (Reglan®).


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  • Physician-developed and -monitored.
    Original Date of Publication: 10 Jun 1998
    Reviewed by: Stephen W. Leslie, M.D., F.A.C.S., Stanley J. Swierzewski, III, M.D.
    Last Reviewed: 23 Jul 2008

    Kidney Stones, Pain Medications reprinted with permission from urologychannel.com
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    This page last modified: 02 Mar 2009

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